Liver microsomes
Target ID: CHEMBL613373
Organism: Homo sapiens
Type: SUBCELLULAR
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| RAZAXABAN | CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2ccc3onc(N)c3c2)c(F)c1 | Ki: 0.19 nM |  |
| 2-METHOXYESTRADIOL | COc1cc2c(cc1O)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12 | GI50: 700.0 nM |  |
| DORAMAPIMOD | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Kd: 0.046 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [9*]n1nc([14*])cc1[14*] | 10.09 | 65 |  |
| [5*]N[5*] | 10.09 | 65 |  |
| [5*]N1CCOCC1 | 10.34 | 39 |  |
| [16*]c1ccc(C)cc1 | 10.34 | 39 |  |
| [1*]C([1*])=O | 10.34 | 39 |  |