Lysyl-tRNA synthetase
Target ID: CHEMBL5575
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| TOZASERTIB | Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 | Ki: 0.6 nM |  |
| CRIZOTINIB | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | IC50: 8.0 nM |  |
| IMATINIB | Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 | IC50: 40.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [5*]N1CCN(C)CC1 | 8.31 | 78 |  |
| [5*]N[5*] | 8.31 | 78 |  |
| [1*]C([6*])=O | 8.31 | 78 |  |
| [16*]c1ccc([16*])cc1 | 8.31 | 78 |  |
| O=C(Nc1ccc(Sc2nc(Nc3cc[nH]n3)cc(N3CCNCC3)n2)cc1)C1CC1 | 9.22 | 39 |  |