Histone-lysine N-methyltransferase SETD7
Target ID: CHEMBL5523
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| TAMOXIFEN | CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 | IC50: 6750.0 nM |  |
| BORTEZOMIB | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O | Ki: 0.62 nM |  |
| DAIDZEIN | O=c1c(-c2ccc(O)cc2)coc2cc(O)ccc12 | Suppression: 22.0 % |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [16*]c1ccccc1 | 7.52 | 67 |  |
| [1*]C([6*])=O | 9.21 | 39 |  |
| O=C(NCCc1ccccc1)c1cnccn1 | 9.21 | 39 |  |
| [1*]C(=O)[C@@H]([4*])C[8*] | 9.21 | 39 |  |
| [5*]N[5*] | 9.21 | 39 |  |