Phosphodiesterase 1C
Target ID: CHEMBL4619
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| ROLIPRAM | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 | IC50: 1000.0 nM |  |
| CIPAMFYLLINE | Nc1nc2c([nH]1)c(=O)n(CC1CC1)c(=O)n2CC1CC1 | Inhibition: 5.0 % |  |
| ZAPRINAST | CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1 | IC50: 1750000.0 nM |  |
| THEOPHYLLINE | Cn1c(=O)c2[nH]cnc2n(C)c1=O | ED50: 18.5 mg.kg-1 |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]O[3*] | 4.38 | 78 |  |
| O=C1CC(c2cccc(OC3CCCC3)c2)CN1 | 6.0 | 39 |  |
| [16*]c1ccc([16*])c([16*])c1 | 6.0 | 39 |  |
| [15*]C1CCCC1 | 6.0 | 39 |  |
| [3*]OC | 6.0 | 39 |  |