NAD-dependent deacetylase sirtuin 3
Target ID: CHEMBL4461
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| FLUVASTATIN | CC(C)n1c(/C=C/C(O)CC(O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc21 | IC50: 28.0 nM |  |
| SUNITINIB | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | IC50: 80.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [7*]C[8*] | 7.27 | 63 |  |
| [7*]C1C(=O)Nc2ccc(F)cc21 | 7.1 | 39 |  |
| [5*]N[5*] | 7.1 | 39 |  |
| [4*]CC | 7.1 | 39 |  |
| [5*]N([5*])[5*] | 7.1 | 39 |  |