11-beta-hydroxysteroid dehydrogenase 2
Target ID: CHEMBL3746
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| FUROSEMIDE | NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl | Ki: 100000.0 nM |  |
| GLYCYRRHIZIN | CC1(C)[C@@H](O[C@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12 | Protection: 15.0 % |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [6*]C(=O)O | 4.0 | 31 |  |
| [16*]c1cc(Cl)c(S(N)(=O)=O)cc1[16*] | 4.0 | 24 |  |
| [14*]c1ccco1 | 4.0 | 24 |  |
| [5*]N[5*] | 4.0 | 24 |  |
| [4*]C[8*] | 4.0 | 24 |  |