Phosphodiesterase 1A
Target ID: CHEMBL3421
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| ROLIPRAM | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 | IC50: 1000.0 nM |  |
| SILDENAFIL | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12 | Pc: 87000000.0 cm s-1 |  |
| TADALAFIL | CN1CC(=O)N2[C@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O | IC50: 6.7 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]O[3*] | 6.0 | 78 |  |
| O=C1CC(c2cccc(OC3CCCC3)c2)CN1 | 6.0 | 39 |  |
| [16*]c1ccc([16*])c([16*])c1 | 6.0 | 39 |  |
| [15*]C1CCCC1 | 6.0 | 39 |  |
| [3*]OC | 6.0 | 39 |  |