IL6Ralpha/GP130
Target ID: CHEMBL3137266
Organism: Homo sapiens
Type: PROTEIN-PROTEIN INTERACTION
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| BAZEDOXIFENE | Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12 | IC50: 23.0 nM |  |
| RALOXIFENE | O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12 | IC50: 1.8 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [16*]c1ccc(O)cc1 | 8.18 | 55 |  |
| [16*]c1ccc([16*])cc1 | 8.18 | 55 |  |
| [3*]O[3*] | 8.18 | 55 |  |
| [4*]CC[4*] | 8.18 | 55 |  |
| [9*]n1c([14*])c(C)c2cc(O)ccc21 | 7.64 | 28 |  |