Melanocortin receptor 4
Target ID: CHEMBL259
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| AFAMELANOTIDE | CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C | Ki: 0.5 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [1*]C(=O)[C@@H]([4*])CCC(=O)O | 9.3 | 37 |  |
| [1*]C(=O)[C@@H]([4*])C[8*] | 9.3 | 37 |  |
| [1*]C(=O)[C@@H]([4*])CCC[4*] | 9.3 | 37 |  |
| [16*]c1c[nH]c2ccccc12 | 9.3 | 37 |  |
| [14*]c1c[nH]cn1 | 9.3 | 37 |  |