CHP-134
Target ID: CHEMBL2366128
Organism: Homo sapiens
Type: CELL-LINE
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| VORINOSTAT | O=C(CCCCCCC(=O)Nc1ccccc1)NO | Inhibition: 100.0 % |  |
| DORAMAPIMOD | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Kd: 0.046 nM |  |
| MOTESANIB | CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 | Kd: 1100.0 nM |  |
| BORTEZOMIB | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O | Ki: 0.62 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [5*]N[5*] | 8.5 | 156 |  |
| [16*]c1ccccc1 | 9.21 | 78 |  |
| [1*]C([6*])=O | 7.58 | 78 |  |
| [1*]C(=O)CCCCCCC(=O)NO | None | 39 |  |
| c1ccccc1 | None | 39 |  |