Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
Target ID: CHEMBL2221345
Organism: Homo sapiens
Type: PROTEIN FAMILY
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| EMETINE | CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 | IC50: 40.0 nM |  |
| BORTEZOMIB | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O | Ki: 0.62 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [16*]c1ccccc1 | 9.21 | 39 |  |
| [1*]C([6*])=O | 9.21 | 39 |  |
| O=C(NCCc1ccccc1)c1cnccn1 | 9.21 | 39 |  |
| [1*]C(=O)[C@@H]([4*])C[8*] | 9.21 | 39 |  |
| [5*]N[5*] | 9.21 | 39 |  |