Nucleoside diphosphate kinase 2
Target ID: CHEMBL2160
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| RAF-265 | Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 | Kd: 10000.0 nM |  |
| SARACATINIB | CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 | IC50: 2.7 nM |  |
| ALVOCIDIB | CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 | IC50: 330.0 nM |  |
| MILCICLIB | CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 | IC50: 10000.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [5*]N[5*] | 6.19 | 117 |  |
| [16*]c1ccc([16*])cc1 | 5.0 | 78 |  |
| [3*]O[3*] | 6.78 | 78 |  |
| [5*]N1CCN(C)CC1 | 6.78 | 78 |  |
| [14*]c1cc([16*])ccn1 | 5.0 | 39 |  |