Interleukin-8
Target ID: CHEMBL2157
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| ETHACRYNIC ACID | C=C(CC)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl | mequiv of Na+/kg: 4.14 0-5h |  |
| AMPHOTERICIN B | C[C@@H]1[C@H](O)[C@@H](C)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@H]2O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@H]1C)C[C@H](O)[C@H]2C(=O)O | MIC: 4000.0 ug.mL-1 |  |
| DIETHYLSTILBESTROL | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | EC50: 9.0 nM |  |
| BITHIONOL | Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O | Control current: 198.6 % |  |
| TRIMETHOPRIM | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC | IC50: 12000.0 nM |  |
| ESTRADIOL | C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O | IC50: 1.5 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]OC | 4.92 | 39 |  |
| [16*]c1cc([16*])c([16*])c([16*])c1 | 4.92 | 39 |  |
| [8*]C[8*] | 4.92 | 39 |  |
| c1ccc(Cc2cncnc2)cc1 | 4.92 | 39 |  |
| [16*]c1cnc(N)nc1N | 4.92 | 39 |  |