NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)
Target ID: CHEMBL2111387
Organism: Homo sapiens
Type: CHIMERIC PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| BOSUTINIB | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | IC50: 1.3 nM |  |
| CRIZOTINIB | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | IC50: 8.0 nM |  |
| IMATINIB | Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 | IC50: 40.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]O[3*] | 8.49 | 78 |  |
| [5*]N1CCN(C)CC1 | 8.14 | 78 |  |
| [5*]N[5*] | 8.14 | 78 |  |
| [4*]CCC[4*] | 8.89 | 39 |  |
| [3*]OC | 8.89 | 39 |  |