Dual specificity mitogen-activated protein kinase kinase; MEK1/2
Target ID: CHEMBL2111289
Organism: Homo sapiens
Type: PROTEIN FAMILY
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| AZD-1152-HQPA | CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 | Ki: 10000.0 nM |  |
| ZD-4190 | COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCn1ccnn1 | IC50: 700.0 nM |  |
| SORAFENIB | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | IC50: 12.0 nM |  |
| SARACATINIB | CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 | IC50: 2.7 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]O[3*] | 6.91 | 156 |  |
| [5*]N[5*] | 6.91 | 156 |  |
| [14*]c1cc([14*])[nH]n1 | 5.0 | 39 |  |
| [1*]C(=O)C[8*] | 5.0 | 39 |  |
| [4*]CC | 5.0 | 39 |  |