Phosphodiesterase; PDE3 & PDE4
Target ID: CHEMBL2095153
Organism: Homo sapiens
Type: SELECTIVITY GROUP
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| PAPAVERINE | COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC | Blood pressure: -23.0 mmHg |  |
| INAMRINONE | Nc1cc(-c2ccncc2)c[nH]c1=O | Mean ED50: 0.389 mg kg-1 |  |
| ROLIPRAM | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 | IC50: 1000.0 nM |  |
| ZAPRINAST | CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1 | IC50: 1750000.0 nM |  |
| MILRINONE | Cc1[nH]c(=O)c(C#N)cc1-c1ccncc1 | Mean ED50: 0.037 mg kg-1 |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]OC | 6.0 | 78 |  |
| [16*]c1ccc([16*])c([16*])c1 | 6.0 | 78 |  |
| [3*]O[3*] | 4.38 | 78 |  |
| O=c1ccc(-c2ccncc2)c[nH]1 | None | 62 |  |
| [16*]c1ccncc1 | None | 62 |  |