Phosphodiesterase 3
Target ID: CHEMBL2094125
Organism: Homo sapiens
Type: PROTEIN FAMILY
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| INAMRINONE | Nc1cc(-c2ccncc2)c[nH]c1=O | Mean ED50: 0.389 mg kg-1 |  |
| CIPAMFYLLINE | Nc1nc2c([nH]1)c(=O)n(CC1CC1)c(=O)n2CC1CC1 | Inhibition: 5.0 % |  |
| ZAPRINAST | CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1 | IC50: 1750000.0 nM |  |
| THEOPHYLLINE | Cn1c(=O)c2[nH]cnc2n(C)c1=O | ED50: 18.5 mg.kg-1 |  |
| SILDENAFIL | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12 | Pc: 87000000.0 cm s-1 |  |
| ZARDAVERINE | COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F | IC50: 10000.0 nM |  |
| ISOMAZOLE | COc1cc([S+](C)[O-])ccc1-c1nc2cnccc2[nH]1 | ED50: 0.05 dp/dt |  |
| CILOMILAST | COc1ccc([C@]2(C#N)CC[C@@H](C(=O)O)CC2)cc1OC1CCCC1 | IC50: 100.0 nM |  |
| LODENAFIL | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CCO)CC4)ccc3OCC)nc12 | IC50: 460.0 nM |  |
| CILOSTAMIDE | CN(C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1)C1CCCCC1 | EC50: 1200.0 nM |  |
| ROLIPRAM | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 | IC50: 1000.0 nM |  |
| SULMAZOLE | COc1cc([S+](C)[O-])ccc1-c1nc2cccnc2[nH]1 | Delta: 163.0 % |  |
| VARDENAFIL HYDROCHLORIDE | CCCc1nc(C)c2c(O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)nn12.Cl | IC50: 180.0 nM |  |
| DIPYRIDAMOLE | OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 | IC50: 500.0 nM |  |
| MILRINONE | Cc1[nH]c(=O)c(C#N)cc1-c1ccncc1 | Mean ED50: 0.037 mg kg-1 |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]O[3*] | 5.79 | 273 |  |
| [3*]OC | 6.0 | 195 |  |
| [12*]S(=O)(=O)c1ccc([16*])c([16*])c1 | 6.54 | 117 |  |
| [8*]CCC | 6.54 | 117 |  |
| [4*]CC | 6.54 | 117 |  |