MAP kinase p38
Target ID: CHEMBL2094115
Organism: Homo sapiens
Type: PROTEIN FAMILY
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| DORAMAPIMOD | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Kd: 0.046 nM |  |
| NEFLAMAPIMOD | O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl | IC50: 22.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [5*]N1CCOCC1 | 10.34 | 39 |  |
| [9*]n1nc([14*])cc1[14*] | 10.34 | 39 |  |
| [16*]c1ccc(C)cc1 | 10.34 | 39 |  |
| [5*]N[5*] | 10.34 | 39 |  |
| [1*]C([1*])=O | 10.34 | 39 |  |