Thyroid hormone receptor beta-1
Target ID: CHEMBL1947
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| INAMRINONE | Nc1cc(-c2ccncc2)c[nH]c1=O | Mean ED50: 0.389 mg kg-1 |  |
| GENTIAN VIOLET | CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1.[Cl-] | Lysis: 100.0 % |  |
| MIFEPRISTONE | CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C | IC50: 0.028 nM |  |
| SELICICLIB | CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 | IC50: 450.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [5*]N(C)C | 10.55 | 53 |  |
| [16*]c1ccc([16*])cc1 | 10.55 | 53 |  |
| [5*]N[5*] | 6.35 | 39 |  |
| [4*]C[8*] | 6.35 | 39 |  |
| c1ccc(CNc2ncnc3[nH]cnc23)cc1 | 6.35 | 39 |  |