Alpha-2c adrenergic receptor
Target ID: CHEMBL1916
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| BRIMONIDINE | Brc1c(NC2=NCCN2)ccc2nccnc12 | pC25: 1.55 uM kg-1 |  |
| ASTROMICIN | CO[C@H]1[C@@H](O)[C@H](N)[C@@H](O[C@H]2O[C@H]([C@H](C)N)CC[C@H]2N)[C@H](O)[C@@H]1N(C)C(=O)CN | Hepatotoxicity (moderate): 7.3 % |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [5*]NC1=NCCN1 | None | 14 |  |
| c1cnc2cc(NC3=NCCN3)ccc2n1 | None | 14 |  |
| [16*]c1ccc2nccnc2c1Br | None | 14 |  |
| [3*]OC | None | 9 |  |
| [5*]N([5*])C | None | 9 |  |