Serotonin 3a (5-HT3a) receptor
Target ID: CHEMBL1899
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| FALDAPREVIR | C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(=O)C(C)C)n3)nc3c(Br)c(OC)ccc23)CN1C(=O)[C@@H](NC(=O)OC1CCCC1)C(C)(C)C)C(=O)O | IC50: 3.0 nM |  |
| SORAFENIB | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | IC50: 12.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [1*]C([1*])=O | 8.17 | 66 |  |
| [3*]O[3*] | 8.17 | 66 |  |
| [1*]C([6*])=O | 8.17 | 66 |  |
| [5*]N[5*] | 8.17 | 66 |  |
| [5*]NC | 7.92 | 39 |  |