Phosphodiesterase 5A

Target ID: CHEMBL1827

Organism: Homo sapiens

Type: SINGLE PROTEIN

View on ChEMBL

Molecules

Name SMILES Bioactivity Structure
PAPAVERINE COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Blood pressure: -23.0 mmHg
PROXYPHYLLINE CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C Activity: 47.0 %
CIPAMFYLLINE Nc1nc2c([nH]1)c(=O)n(CC1CC1)c(=O)n2CC1CC1 Inhibition: 5.0 %
ZAPRINAST CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1 IC50: 1750000.0 nM
THEOPHYLLINE Cn1c(=O)c2[nH]cnc2n(C)c1=O ED50: 18.5 mg.kg-1
TADALAFIL CN1CC(=O)N2[C@H](c3ccc4c(c3)OCO4)c3[nH]c4ccccc4c3C[C@@H]2C1=O IC50: 6.7 nM
SILDENAFIL CITRATE CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12.O=C(O)CC(O)(CC(=O)O)C(=O)O IC50: 2.2 nM
SILDENAFIL CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12 Pc: 87000000.0 cm s-1
ZARDAVERINE COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F IC50: 10000.0 nM
CARTAZOLATE CCCCNc1c(C(=O)OCC)cnc2c1cnn2CC IC50: 180.0 nM
ISOMAZOLE COc1cc([S+](C)[O-])ccc1-c1nc2cnccc2[nH]1 ED50: 0.05 dp/dt
CILOMILAST COc1ccc([C@]2(C#N)CC[C@@H](C(=O)O)CC2)cc1OC1CCCC1 IC50: 100.0 nM
LODENAFIL CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CCO)CC4)ccc3OCC)nc12 IC50: 460.0 nM
CILOSTAMIDE CN(C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1)C1CCCCC1 EC50: 1200.0 nM
VARDENAFIL CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12 IC50: 0.7 nM
ROLIPRAM COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 IC50: 1000.0 nM
SULMAZOLE COc1cc([S+](C)[O-])ccc1-c1nc2cccnc2[nH]1 Delta: 163.0 %
VARDENAFIL HYDROCHLORIDE CCCc1nc(C)c2c(O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)nn12.Cl IC50: 180.0 nM
DIPYRIDAMOLE OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 IC50: 500.0 nM
MILRINONE Cc1[nH]c(=O)c(C#N)cc1-c1ccncc1 Mean ED50: 0.037 mg kg-1

Top Fragments

SMILES Avg pKi Count Structure
[3*]O[3*] 6.59 390
[3*]OC 6.0 234
[4*]CC 7.53 234
[12*]S(=O)(=O)c1ccc([16*])c([16*])c1 7.72 195
[8*]CCC 7.72 195