15-hydroxyprostaglandin dehydrogenase [NAD+]
Target ID: CHEMBL1293255
Organism: Homo sapiens
Type: SINGLE PROTEIN
Molecules
| Name | SMILES | Bioactivity | Structure |
|---|---|---|---|
| BRIMONIDINE | Brc1c(NC2=NCCN2)ccc2nccnc12 | pC25: 1.55 uM kg-1 |  |
| ZARDAVERINE | COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F | IC50: 10000.0 nM |  |
| DIPYRIDAMOLE | OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1 | IC50: 500.0 nM |  |
Top Fragments
| SMILES | Avg pKi | Count | Structure |
|---|---|---|---|
| [3*]OC | 5.0 | 39 |  |
| O=c1ccc(-c2ccccc2)n[nH]1 | 5.0 | 39 |  |
| [14*]c1ccc(=O)[nH]n1 | 5.0 | 39 |  |
| [16*]c1ccc([16*])c([16*])c1 | 5.0 | 39 |  |
| [3*]OC(F)F | 5.0 | 39 |  |